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                              Strong underlying demand for cancer treatment driving radiotherapy

                              Investment case

                              • Strong demand
                              • Attractive business
                              • Strategic focus
                              • Leading innovations

                              Strong underlying demand for cancer treatment driving radiotherapy

                              Increasing global cancer burden through growing incidence and prevalence as people live longer and cancer survival rates are rising globally.

                              Avarage life expectancy continues to increase.

                              Millions

                              2,5002,0001,5001,000500
                              0
                              900
                              1,401
                              2,091
                              20152030E2050E
                              Age 60+ population

                              Growing cancer incidence and prevalence.

                              Millions

                              5040302010
                              0
                              10
                              12
                              15
                              18
                              20
                              22
                              9
                              11
                              14
                              17
                              19
                              20
                              20
                              25
                              30
                              35
                              40
                              45
                              201820202025E2030E2035E2040E
                              Men
                              Women
                              Total

                              Higher survival rates imply cancer as a chronic condition

                              Technological innovations improve radiotherapy (RT) treatment and more cancer types become relevant for radiotherapy.

                              Unity, our MR-Linac (MRL), that combines a linear accelerator (linac) with magnetic resonance imaging (MRI) is changing the RT market.

                              Clinical need for MRL

                              MRL treatment would be bene-ficial to 25-30% of all RT patients

                              30252015105
                              0
                              24
                              4
                              10
                              4
                              12-15%
                              of all cancer cases
                              25-30%
                              of all RT cases


                              MRL is expanding the role of RT for indications like:

                              • Liver cancer
                              • Stomach cancer
                              • Cervix/Uterus cancer
                              • Pancreas cancer
                              • Head & neck cancer
                              • Oligo metastatic disease
                              • Oesophagus cancer
                              • Lung cancer


                              Large structural differences in the availability of cancer care around the globe.

                              RT market still largely underpenetrated in many geographies.

                              12108642
                              0
                              2.1M
                              1.7%
                              12
                              North America
                              12108642
                              0
                              1.6M
                              2.8%
                              2
                              Latin America & Caribbean
                              12108642
                              0
                              4.3M
                              1.1%
                              5
                              Europe
                              12108642
                              0
                              1.3M
                              3.2%
                              0.3
                              Africa
                              12108642
                              0
                              10.8M
                              2.7%
                              1
                              Asia
                              12108642
                              0
                              0.2M
                              2.4%
                              6
                              Oceania

                              Expected number of new cancer cases 2025 (million new cases)

                              Expected yearly growth in cancer cases 2020-25

                              Number of RT units per capita 2021 (million population)

                              Increasing healthcare spending putting cost pressure on clinics, thus focusing on value-based healthcare to the benefit of cost-efficient treatments like RT.

                              Radiotherapy most cost efficient form of cancer treatment

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                              Important Safety Information: Radiation therapy is not appropriate for all patients. Radiation treatments may cause side effects that can vary depending on the part of the body being treated. In some patients, they can be severe. Treatment sessions may vary in complexity and time. Refer to individual product labeling (instructions for use) for more complete information on product safety and effectiveness for its intended use.

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                              Important Safety Information: Radiation therapy is not appropriate for all patients. Radiation treatments may cause side effects that can vary depending on the part of the body being treated. In some patients, they can be severe. Treatment sessions may vary in complexity and time. Refer to individual product labeling (instructions for use) for more complete information on product safety and effectiveness for its intended use.